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「神経系・腸内細菌・免疫が連携して腫瘍に影響する可能性」の検索結果

227 件中 10 件を表示 (4343 ms) · ⭐ 保存した論文

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("nervous system"[MeSH] OR "brain-gut axis" OR neuroimmune) AND ("gastrointestinal microbiome"[MeSH] OR "gut microbiota" OR "intestinal bacteria") AND ("immune system"[MeSH] OR immunity OR immunomodulation) AND (neoplasms[MeSH] OR tumor OR cancer)

💡 神経-腸-免疫の3要素と腫瘍との相互作用を捉えるため、各要素の主要MeSH用語と類義語をANDで結合

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  • Symbiotic in Alzheimer's disease: modulating the gut-brain axis for neuroimmune homeostasis and cognitive protection.

    Snehashis Mandal, Khadga Raj Aran · Inflammopharmacology · 2026

    Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder defined by progressive cognitive impairment, neuroinflammation, oxidative stress, amyloid-β (Aβ) accumulation, synaptic dysfunction, mitochondrial impairment, and tau hyperphosphorylation. The gut-brain axis (GBA) is a crucial regulatory signaling cascade that links intestinal microbiome composition with both neural health and…

    📄 PubMed で読む (PMID: 41803336)
  • Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective.

    Xia Yu, Yi Zuo, Yang Yang 他 · Expert reviews in molecular medicine · 2025

    Perimenopausal women often experience physiological and psychological decline due to the effects of oestrogen fluctuations and the decline of ovarian function, leading to significantly increased depression rates, decreases in the quality of life and mental health issues. Studies have shown that the gut microbiota exerts anti-perimenopausal depression (PMD) effects via the microbiota-gut-brain (MGB…

    📄 PubMed で読む (PMID: 40905280)
  • Immunological Mechanisms of the Gut-brain-cardiovascular Axis in Coronary Heart Disease with Comorbid Anxiety and Depression.

    Yiwei Xu, Xiaohu Chen · Iranian journal of allergy, asthma, and immunology · 2026

    Coronary heart disease (CHD) is frequently accompanied by anxiety and depression, conditions that markedly worsen cardiovascular outcomes. Increasing evidence indicates that immune dysregulation, driven by gut microbiota alterations, plays a central role in linking psychological disorders with cardiovascular pathology through the gut-brain-cardiovascular axis. This narrative review systematically …

    📄 PubMed で読む (PMID: 42801774)
  • Microbiota-Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma.

    Tareq Nayef AlRamadneh, Renuka Jyothi S, Priya Priyadarshini Nayak 他 · Brain and behavior · 2026

    Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains difficult to treat because of diffuse invasion, immunosuppression, metabolic adaptability, and therapy resistance. This review evaluates how gut microbiota and microbiota-associated neuroinflammatory signaling may contribute to GBM biology and therapeutic response. We synthesized mechanistic, preclinical, translati…

    📄 PubMed で読む (PMID: 42553012)
  • In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part II: Pathology: Part II: Pathology.

    Abi G Yates, Ryan C Pink, Uta Erdbrügger 他 · Journal of extracellular vesicles · 2022

    It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obt…

    📄 PubMed で読む (PMID: 35041301)
  • The gut-immune-brain axis in CNS tumors: Causal roles of microbiota and inflammatory proteins unveiled by Mendelian randomization and single-cell transcriptomics.

    Xianwen Cao, Hui Guo, Kun Wang 他 · Medicine · 2026

    There is a growing number of research suggesting that there is an association between gut microbiota and central nervous system (CNS) tumor. However, the causal relationships and the mediation effects of inflammatory proteins in the associations are unclear. We extracted genetic variants associated with gut microbiota, inflammatory proteins, and 4 subtypes of CNS tumors from published genome-wide …

    📄 PubMed で読む (PMID: 42566596)
  • From mechanisms to therapy: Targeting the gut-brain axis in chronic gastrointestinal pain.

    Xiaofang Chen, Biyu Tan, Gaoxuan Shao 他 · Pharmacological research · 2026

    Chronic gastrointestinal pain (CGP) is a common and often difficult-to-manage symptom in disorders of gut-brain interaction (DGBI). Owing to the limited efficacy of current therapeutic approaches in a subset of patients, a better understanding of gut-brain axis (GBA) dysfunction may facilitate the development of improved treatment strategies. This review summarizes the pathophysiological mechanism…

    📄 PubMed で読む (PMID: 42364834)
  • The gut microbiota-enteric nervous system axis: from bidirectional programming to precision therapeutics in digestive diseases.

    Huimin Li, Ao Ye, Jieyu Song 他 · Frontiers in cellular and infection microbiology · 2026

    The bidirectional communication between the gut microbiota (GM) and the enteric nervous system (ENS) is fundamental for gastrointestinal homeostasis. This review dissects the intricate GM-ENS dialogue, emphasizing its transition from a developmental programmer in early life to a sustained regulator of neural plasticity in adulthood. We synthesize the core signaling mechanisms-microbial metabolites…

    📄 PubMed で読む (PMID: 42359009)
  • Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

    Ya-Fang Zhang, Yi-Yuan Li, Jin Jin 他 · Seminars in immunology · 2026

    Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medulla (SAM) axes, leading to altered glucocorticoid and catecholamine levels that impair immune responses and promote inflammati…

    📄 PubMed で読む (PMID: 42250338)
  • Tryptophan-kynurenine metabolic reprogramming along the gut-brain axis alleviates Alzheimer's pathology.

    Hyunjung Choi, Seok Beom Hong, Yumi Kim 他 · Journal of neuroinflammation · 2026

    The gut–brain axis influences neuroinflammation and metabolic homeostasis in Alzheimer’s disease (AD). Disruption of gut microbiota and barrier function promotes amyloid and tau pathology via immune and metabolic dysregulation. In this study, Limosilactobacillus fermentum SRK414 (SRK414) was orally administered to ADLPAPT mice, resulting in reduced Aβ and tau pathology and improved cognition. Mult…

    📄 PubMed で読む (PMID: 42026585)