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「IBD(炎症性腸疾患)の腸内フローラ、遺伝・環境・多菌種相互作用で病態解明が大幅進展」の検索結果

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("inflammatory bowel diseases"[MeSH] OR IBD OR "Crohn disease"[MeSH] OR "colitis, ulcerative"[MeSH]) AND ("gastrointestinal microbiome"[MeSH] OR "gut microbiota" OR "intestinal flora" OR microbiome) AND (genetic OR "gene-environment interaction"[MeSH] OR "host-microbial interactions"[MeSH] OR "microbial interactions" OR pathogenesis)

💡 IBDとその下位疾患、腸内フローラ関連用語、遺伝・環境・微生物相互作用・病態形成の各要素をANDで結合

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  • The gut immune axis in ulcerative colitis: insights from microbiome research.

    Rufaida Wasim · Molecular biology reports · 2025

    Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease (IBD) marked by inflammation of the colonic mucosa. While its precise aetiology remains unclear, emerging evidence underscores the pivotal role of gut microbiota in UC pathogenesis. In healthy individuals, the gut microbiota contributes to immune modulation, nutrient absorption, and maintenance of intestinal barrier integri…

    📄 PubMed で読む (PMID: 41071393)
  • Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile.

    Wei Chen, Lin Xu, Long Wang 他 · Frontiers in cellular and infection microbiology · 2025

    Clinically, Qing-Re-Hua-Shi Decoction (QRHSD) has been clinically used to treat ulcerative colitis (UC) with satisfactory outcomes and minimal side effects. However, its molecular mechanisms remain unclear. This study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted metabolomics,…

    📄 PubMed で読む (PMID: 40242025)
  • Oral-gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol.

    Hyun Sik Kim, Bo-Hyung Kim, Bora Nam 他 · BMJ open · 2025

    The global burden of chronic immune-mediated inflammatory diseases (IMIDs) is increasing, and rising prevalence rates significantly affect socioeconomic factors and quality of life. Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), along with ankylosing spondylitis (AS), are prominent chronic IMIDs that share overlapping pathophysiological mechanisms. Re…

    📄 PubMed で読む (PMID: 40784769)
  • FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models.

    Zhongqian Jin, Zhaoyang Liu, Jiaxuan Pan 他 · International immunopharmacology · 2024

    Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), presents a significant clinical challenge due to the lack of optimal therapeutic strategies. Emerging evidence suggests that fibroblast growth factor 20 (FGF20) may play a crucial role in mitigating UC symptoms, though the mechanistic underpinnings remain elusive. In this study, a mouse model of UC was established using…

    📄 PubMed で読む (PMID: 39217880)
  • Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?

    Ronaldo Lira-Junior, Carlos Marcelo Figueredo · World journal of gastroenterology · 2016

    Periodontal disease and inflammatory bowel disease (IBD) are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immune-inflammatory response, and both are influenced by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between p…

    📄 PubMed で読む (PMID: 27672291)
  • Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

    Georgina L Hold, Megan Smith, Charlie Grange 他 · World journal of gastroenterology · 2014

    Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has…

    📄 PubMed で読む (PMID: 24574795)
  • Bacillus licheniformis Alleviates DSS-Induced Ulcerative Colitis in Mice by Repairing the Intestinal Barrier and Regulating Gut Microbiota and Its Metabolism.

    Hongwei Ma, Mengen Xu, Ying Yu 他 · Nutrients · 2026

    Inflammatory bowel disease (IBD) is a gut-based idiopathic disease characterized by chronic and relapsing inflammatory progression and intricate pathophysiology. It is now known that the key etiologies of IBD include immune dysregulation, imbalances in the gut microbiota, and metabolic disruptions. Probiotics are now the potential treatment for IBD, due to their ability to regulate the host immune…

    📄 PubMed で読む (PMID: 42075123)
  • The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection.

    Bärbel Stecher · Microbiology spectrum · 2015

    The healthy human intestine is colonized by as many as 1014 bacteria belonging to more than 500 different species forming a microbial ecosystem of unsurpassed diversity, termed the microbiota. The microbiota's various bacterial members engage in a physiological network of cooperation and competition within several layers of complexity. Within the last 10 years, technological progress in the field …

    📄 PubMed で読む (PMID: 26185088)
  • Diet therapy for inflammatory bowel diseases: The established and the new.

    Franziska Durchschein, Wolfgang Petritsch, Heinz F Hammer 他 · World journal of gastroenterology · 2016

    Although patients with inflammatory bowel diseases (IBD) have a strong interest in dietary modifications as part of their therapeutic management, dietary advice plays only a minor part in published guidelines. The scientific literature shows that dietary factors might influence the risk of developing IBD, that dysbiosis induced by nutrition contributes to the pathogenesis of IBD, and that diet may…

    📄 PubMed で読む (PMID: 26900283)
  • Gut metagenome and spondyloarthritis.

    Thierry Schaeverbeke, Marie-Elise Truchetet, Christophe Richez 他 · Joint bone spine · 2013

    📄 PubMed で読む (PMID: 23806346)