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「膵臓がんと腸内細菌叢:真菌の意外な役割」の検索結果

11 件中 10 件を表示 (3899 ms) · ⭐ 保存した論文

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("pancreatic neoplasms"[MeSH] OR "pancreatic cancer") AND ("gastrointestinal microbiome"[MeSH] OR "gut microbiota" OR "intestinal microbiome") AND (fungi[MeSH] OR mycobiome OR "fungal microbiota")

💡 膵臓がん、腸内細菌叢、真菌の3要素をMeSH用語と同義語で組み合わせ、真菌叢(mycobiome)も含めた包括的検索

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🔍 PubMed の検索結果

  • Isolation of Bacteria and Fungi from Human Pancreatic Tumors and Duodenum.

    Dominik Awad, Holly Attebury, Ryan Hong 他 · Gut microbes · 2026

    Pancreatic ductal adenocarcinoma has a unique tumor microbiome, and the depletion of gut bacteria or fungi using antibiotic/antifungal cocktails has been shown to decrease pancreatic tumor burden in mice. However, functional studies evaluating the role of tumor-associated microbes are few due to the limited availability of clinically relevant microbiota. Here, we describe in detail an effective wo…

    📄 PubMed で読む (PMID: 42411381)
  • Microbial profile in bile from pancreatic and extra-pancreatic biliary tract cancer.

    Paola Di Carlo, Nicola Serra, Teresa Maria Assunta Fasciana 他 · PloS one · 2024

    Dysbiotic biliary bacterial profile is reported in cancer patients and is associated with survival and comorbidities, raising the question of its effect on the influence of anticancer drugs and, recently, the suggestion of perichemotherapy antibiotics in pancreatic cancer patients colonized by the Escherichia coli and Klebsiella pneumoniae. In this study, we investigated the microbial communities …

    📄 PubMed で読む (PMID: 38381746)
  • The potential of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma.

    K Kaźmierczak-Siedlecka, E Stachowska, M Folwarski 他 · European review for medical and pharmacological sciences · 2021

    The aim of this paper was to discuss the potency of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma. We analysed the available up-to-date literature (PubMed, Embase, Google Scholar databases) regarding the link between gut microbiome and early detection of pancreatic cancer, as well as hepatocellular carcinoma. The followi…

    📄 PubMed で読む (PMID: 34919227)
  • Role of Fungi in Tumorigenesis: Promises and Challenges.

    Silvia Guglietta, Xin Li, Deepak Saxena 他 · Annual review of pathology · 2025

    The mycobiome plays a key role in the host immune responses in homeostasis and inflammation. Recent studies suggest that an imbalance in the gut's fungi contributes to chronic, noninfectious diseases such as obesity, metabolic disorders, and cancers. Pathogenic fungi can colonize specific organs, and the gut mycobiome has been linked to the development and progression of various cancers, including…

    📄 PubMed で読む (PMID: 39854185)
  • Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis.

    Karolina Kaźmierczak-Siedlecka, Aleš Dvořák, Marcin Folwarski 他 · Cancers · 2020

    The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Seve…

    📄 PubMed で読む (PMID: 32455985)
  • The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.

    Berk Aykut, Smruti Pushalkar, Ruonan Chen 他 · Nature · 2019

    Bacterial dysbiosis accompanies carcinogenesis in malignancies such as colon and liver cancer, and has recently been implicated in the pathogenesis of pancreatic ductal adenocarcinoma (PDA)1. However, the mycobiome has not been clearly implicated in tumorigenesis. Here we show that fungi migrate from the gut lumen to the pancreas, and that this is implicated in the pathogenesis of PDA. PDA tumours…

    📄 PubMed で読む (PMID: 31578522)
  • The hidden players: The mycobiome of pancreatic ductal adenocarcinoma tumors.

    Camille Estrin, Sébastien Bertout, Virginie Bellet 他 · Microbiological research · 2026

    The microorganisms that inhabit the human body are known to play a role in human health and disease. Continuing to elucidate their specific role in disease progression is, however, necessary. The imbalance of these microorganisms-known as dysbiosis-has been linked to a myriad of intestinal diseases, and more recently to cancer. Despite making up less than 0.1 % of the human microbiome, dysbiosis o…

    📄 PubMed で読む (PMID: 41205302)
  • The Role of the Microbiome in Pancreas Cancer: The Evolving Influence of the Fungal Mycobiome.

    Dominik Awad, Donnele Daley · The Surgical clinics of North America · 2025

    The gut microbiome has been shown to impact the progression of pancreatic ductal adenocarcinoma and the tumor's response to therapy. Microbial dysbiosis or changes in the healthy gut microbiome has been implicated in pancreatic cancer patients and influences immune cell differentiation and cancer cell behavior in the tumor microenvironment. This article summarizes the key findings from studies inv…

    📄 PubMed で読む (PMID: 41077432)
  • The Fecal Mycobiome in Chronic Pancreatitis Is Characterized by an Increase in Candida species and Nakaseomyces.

    Przemyslaw M Podgorny, Stefan Weiss, Corinna Bang 他 · Clinical and translational gastroenterology · 2025

    The exocrine pancreas is an important determinant of the intestinal microbiome composition and stability. Although chronic pancreatitis (CP) is known to severely affect the bacterial community, its impact on the intestinal mycobiome is currently unknown. A total of 93 patients with clinical and imaging evidence of CP were prospectively recruited and compared with 2 equally sized matched control co…

    📄 PubMed で読む (PMID: 40358410)
  • Commensal fungi in intestinal health and disease.

    Kyla S Ost, June L Round · Nature reviews. Gastroenterology & hepatology · 2023

    The microbiota is known to influence several facets of mammalian development, digestion and disease. Most studies of the microbiota have focused on the bacterial component, but the importance of commensal fungi in health and disease is becoming increasingly clear. Although fungi account for a smaller proportion of the microbiota than bacteria by number, they are much larger and therefore account f…

    📄 PubMed で読む (PMID: 37479823)