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「腸内細菌・免疫・神経が織りなす「超システム」とは」の検索結果

4,114 件中 10 件を表示 (4601 ms) · ⭐ 保存した論文

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("gastrointestinal microbiome"[MeSH] OR "gut microbiota" OR "intestinal microbiota") AND ("immune system"[MeSH] OR immunity OR immunology) AND ("nervous system"[MeSH] OR "brain-gut axis" OR "gut-brain axis" OR neuroimmune OR neurological)

💡 腸内細菌・免疫・神経の相互作用を表す「超システム」を、腸内細菌叢、免疫系、神経系の3要素のAND検索で表現し、脳腸相関の概念も含めました

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🔍 PubMed の検索結果

  • Minimally invasive vagus nerve stimulation modulates mast cell degranulation via the microbiota-gut-brain axis to ameliorate blood-brain barrier and intestinal barrier damage following ischemic stroke.

    Yanan Wang, Qianqian Tan, Mingdong Pan 他 · International immunopharmacology · 2024

    Mast cells (MCs) play a significant role in various diseases, and their activation and degranulation can trigger inflammatory responses and barrier damage. Several studies have indicated that vagus nerve stimulation (VNS) exerts ameliorates neurological injury, and regulates gut MC degranulation. However, there is limited research on the modulatory effect of VNS on MCs in both the gut and brain in…

    📄 PubMed で読む (PMID: 38603861)
  • Resilience and immunity.

    Robert Dantzer, Sheldon Cohen, Scott J Russo 他 · Brain, behavior, and immunity · 2018

    Resilience is the process that allows individuals to adapt to adverse conditions and recover from them. This process is favored by individual qualities that have been amply studied in the field of stress such as personal control, positive affect, optimism, and social support. Biopsychosocial studies on the individual qualities that promote resilience show that these factors help protect against th…

    📄 PubMed で読む (PMID: 30102966)
  • Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects.

    Min Zhou, Jing Yu, Xuewei Li 他 · Journal of cellular and molecular medicine · 2024

    Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony and social development. The aetiology of PCOS is complex. In recent years, many scholars have found that its pathogenesis was related to the imbalance of gut microbiota. Gut mic…

    📄 PubMed で読む (PMID: 38546608)
  • The gut microbiota-brain-CAR T cell axis: a systematic review of gut microbiome modulation and its impact on neurological complications and treatment responses in CAR T cell therapy.

    Ashvath Arumugam Pillai, Sai K Reddy Pasya, Gaurav Kansal 他 · Frontiers in immunology · 2025

    CAR T-cell therapy represents a substantial advance for relapsed/refractory hematologic cancers, but toxicities still limit its benefits. A particular concern is immune effector cell-associated neurotoxicity syndrome (ICANS), whose mechanisms remain only partly resolved. In parallel, work across immunology and neurogastroenterology shows that gut microbial communities can shape systemic inflammati…

    📄 PubMed で読む (PMID: 41562078)
  • The gut-organ axis: Clinical aspects and immune mechanisms.

    Naoto Fukasawa, Junya Tsunoda, Shogo Sunaga 他 · Allergology international : official journal of the Japanese Society of Allergology · 2025

    The gut-brain axis exemplifies the bidirectional connection between the intestines and the brain, as evidenced by the impact of severe stress on gastrointestinal symptoms including abdominal pain and diarrhea, and conversely, the influence of abdominal discomfort on mood. Clinical observations support the notion of the gut-brain connection, including an increased prevalence of inflammatory bowel d…

    📄 PubMed で読む (PMID: 39979198)
  • Macrophages dynamically integrate neuro-immune-microbial network signals: their role in gastrointestinal motility disorders and targeting potential.

    Weiqing Yang, Sunan Yong, Qiang Zhang 他 · Frontiers in immunology · 2026

    Gastrointestinal motility disorders are pathologically characterized by dysregulation of the tripartite network comprising the intestinal immune system, the enteric nervous system, and the gut microbiota. Targeted medicines that target important nodes in this network are desperately needed, and macrophages-tissue-resident immune cells with a high degree of plasticity-are showing promise as therape…

    📄 PubMed で読む (PMID: 42317334)
  • Probiotic, prebiotic, and synbiotic interventions targeting the early-life gut-brain axis: A systematic review of randomized controlled trials.

    Salvatore Michele Carnazzo, Alessandro Vitello, Fabio Allia 他 · Journal of neuroimmunology · 2026

    Early life represents a critical window for maturation of the gut microbiota, mucosal immunity, and neuroimmune pathways underpinning the gut-brain axis (GBA). Probiotic, prebiotic, and synbiotic interventions have been proposed to modulate these processes; however, their mechanistic effects on GBA-relevant biomarkers in humans remain unclear. We conducted a systematic review of randomized control…

    📄 PubMed で読む (PMID: 42330779)
  • Beyond Amyloid: Evolutionary and Immune-Metabolic Perspectives on Alzheimer's Disease.

    George B Stefano · Frontiers in bioscience (Landmark edition) · 2026

    Alzheimer's disease (AD) is increasingly recognized as a multifactorial and systems-level disorder that extends beyond the classical amyloid cascade hypothesis. Rather than dismissing established concepts such as tau pathology, synaptic dysfunction, vascular compromise, mitochondrial abnormalities, and impaired proteostasis, emerging evidence suggests that these processes may interact dynamically …

    📄 PubMed で読む (PMID: 42411493)
  • The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation.

    Chunliang Xu, Sung Kyun Lee, Dachuan Zhang 他 · Immunity · 2020

    Psychological stress has adverse effects on various human diseases, including those of the cardiovascular system. However, the mechanisms by which stress influences disease activity remain unclear. Here, using vaso-occlusive episodes (VOEs) of sickle cell disease as a vascular disease model, we show that stress promotes VOEs by eliciting a glucocorticoid hormonal response that augments gut permeab…

    📄 PubMed で読む (PMID: 32735844)
  • The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria.

    Hartmut Wekerle · Rheumatology (Oxford, England) · 2016

    In a transgenic model of spontaneous experimental autoimmune encephalomyelitis, autoimmune attack against the CNS requires the presence of an intact commensal gut flora. Extending this observation to human autoimmune disease, such as multiple sclerosis, we postulate that the pathogenic reaction requires the coincidence of at least three factors: a permissive genetic disposition, a pro-inflammatory…

    📄 PubMed で読む (PMID: 27856664)