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「腸内細菌の乱れが関節リウマチと関連、新たな治療の可能性」の検索結果

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("gastrointestinal microbiome"[MeSH] OR "gut microbiota" OR "intestinal microbiota" OR dysbiosis) AND ("arthritis, rheumatoid"[MeSH] OR "rheumatoid arthritis") AND (therapy OR treatment OR therapeutic)

💡 腸内細菌叢の乱れ(dysbiosis)と関節リウマチの関連、治療可能性に焦点を当てたクエリ

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  • Intestinal permeability disturbances: causes, diseases and therapy.

    Barbara Macura, Aneta Kiecka, Marian Szczepanik 他 · Clinical and experimental medicine · 2024

    Nowadays, a pathological increase in the permeability of the intestinal barrier (the so-called leaky gut) is increasingly being diagnosed. This condition can be caused by various factors, mainly from the external environment. Damage to the intestinal barrier entails a number of adverse phenomena: dysbiosis, translocation of microorganisms deep into the intestinal tissue, immune response, developme…

    📄 PubMed で読む (PMID: 39340718)
  • Emerging role of gut microbiota in autoimmune diseases.

    Xinyi Wang, Wei Yuan, Chunjuan Yang 他 · Frontiers in immunology · 2024

    Accumulating studies have indicated that the gut microbiota plays a pivotal role in the onset of autoimmune diseases by engaging in complex interactions with the host. This review aims to provide a comprehensive overview of the existing literatures concerning the relationship between the gut microbiota and autoimmune diseases, shedding light on the complex interplay between the gut microbiota, the…

    📄 PubMed で読む (PMID: 38765017)
  • The gut-joint axis in rheumatoid arthritis.

    Mario M Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro 他 · Nature reviews. Rheumatology · 2021

    Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at mucosal sites as a consequence of interactions between the mucosal immune system and an aberrant local microbiota, and then transitions to involve the synovial joints. Alterations in the composition of the microbial flora in …

    📄 PubMed で読む (PMID: 33674813)
  • Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities.

    Ting Zhao, Yuanyuan Wei, Youyang Zhu 他 · Frontiers in immunology · 2022

    Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. Microbial infection is considered a crucial inducer of RA. Alterations in the composition of intestinal bacteria in individuals with preclinical and established RA suggest a vital role of the gut microbiota in immune dysfunction characteristic of RA. However, the mechanisms by which gut dysbiosis contribut…

    📄 PubMed で読む (PMID: 36159786)
  • Rheumatoid arthritis and the intestinal microbiome: probiotics as a potential therapy.

    Yang Yang, Qing Hong, Xuehong Zhang 他 · Frontiers in immunology · 2024

    Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by swollen joints, discomfort, stiffness, osteoporosis, and reduced functionality. Genetics, smoking, dust inhalation, high BMI, and hormonal and gut microbiota dysbiosis are all likely causes of the onset or development of RA, but the underlying mechanism remains unknown. Compared to healthy controls, patients with RA have …

    📄 PubMed で読む (PMID: 38510244)
  • An update on periodontal inflammation and bone loss.

    Mingzhu Zhang, Yali Liu, Hamideh Afzali 他 · Frontiers in immunology · 2024

    Periodontal disease is a chronic inflammatory condition that affects the supporting structures of the teeth, including the periodontal ligament and alveolar bone. Periodontal disease is due to an immune response that stimulates gingivitis and periodontitis, and its systemic consequences. This immune response is triggered by bacteria and may be modulated by environmental conditions such as smoking …

    📄 PubMed で読む (PMID: 38919613)
  • Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases.

    Paulina Belvoncikova, Martin Maronek, Roman Gardlik 他 · International journal of molecular sciences · 2022

    Gut microbiota dysbiosis has recently been reported in a number of clinical states, including neurological, psychiatric, cardiovascular, metabolic and autoimmune disorders. Yet, it is not completely understood how colonizing microorganisms are implicated in their pathophysiology and molecular pathways. There are a number of suggested mechanisms of how gut microbiota dysbiosis triggers or sustains …

    📄 PubMed で読む (PMID: 36142642)
  • Nutrition and its role in prevention and management of rheumatoid arthritis.

    Elena Nikiphorou, Elena Philippou · Autoimmunity reviews · 2023

    Accumulating research evidence suggests that nutrition might be implicated in the risk of development and in the management of autoimmune disease, including rheumatoid arthritis (RA), characterized by immune-inflammatory response. Nutrition can have direct roles through the provision of pro- or anti-inflammatory foods, and indirect roles through management of co-morbidity management. The review up…

    📄 PubMed で読む (PMID: 37182439)
  • Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis.

    Haijian Sun, Yunke Guo, Haidan Wang 他 · Gut · 2023

    Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the development of RA. Microbiota profiling in patients with RA and healthy individuals was investigated via 16S rDNA bacterial gene sequencing and shotgun metagenomics. Collagen-induced arthritic mice and TNF-α transgenic mice were …

    📄 PubMed で読む (PMID: 36604114)
  • The impact of the gut microbiome on extra-intestinal autoimmune diseases.

    Eiji Miyauchi, Chikako Shimokawa, Alex Steimle 他 · Nature reviews. Immunology · 2023

    The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic polymorphisms, infections and smoking, environmental triggers have been considered. Recent sequencing-based approaches have revealed that patients with extra-intestinal ADs, such as multiple sclerosis, rheumatoid arthritis, …

    📄 PubMed で読む (PMID: 35534624)