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「更年期と認知機能、エストロゲン変動が脳に与える影響を科学で読み解く」の検索結果

198 件中 10 件を表示 (5171 ms) · ⭐ 保存した論文

AI が生成した英語クエリを見る 
(menopause[MeSH] OR climacteric OR perimenopause) AND (cognition[MeSH] OR "cognitive function" OR "cognitive decline") AND (estrogen[MeSH] OR estradiol OR "estrogen fluctuation" OR "hormonal changes") AND (brain[MeSH] OR "brain function" OR neuroplasticity)

💡 更年期・認知機能・エストロゲン変動の各概念をMeSH+同義語で網羅し、ANDで組み合わせました

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🔍 PubMed の検索結果

  • Effects of long-term hormone therapy on cholinergic synaptic concentrations in healthy postmenopausal women.

    Y R Smith, S Minoshima, D E Kuhl 他 · The Journal of clinical endocrinology and metabolism · 2001

    Experimental evidence suggests that gonadal steroids regulate brain neurochemical systems associated with cognitive function, such as the cholinergic system. This study examines the effect of long-term postmenopausal hormone therapy on the brain concentrations of cholinergic synaptic terminals in women using single photon emission computed tomography and the radiotracer [(123)I]iodobenzovesamicol …

    📄 PubMed で読む (PMID: 11158031)

  • Estrogen treatment affects brain functioning after menopause.

    Ulrike Bayer, Markus Hausmann · Menopause international · 2011

    Sex hormones have powerful neuromodulatory effects on functional brain organization and cognitive functioning. This paper reviews findings from studies investigating the influence of sex hormones in postmenopausal women with and without hormone therapy (HT). Functional brain organization was investigated using different behavioural tasks in postmenopausal women using either estrogen therapy or com…

    📄 PubMed で読む (PMID: 22120942)

  • The mysterious effect of reproductive hormones on cognitive function: scientific knowledge in search of an application.

    C L Harden · The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia · 2000

    📄 PubMed で読む (PMID: 11252925)

  • Cognitive function at menopause: neuroendocrine implications for the study of the aging brain.

    A Costa, R E Nappi, E Sinforiani 他 · Functional neurology · 1997

    📄 PubMed で読む (PMID: 9218973)

  • The neurobiology of gonadal hormones and cognitive decline in late life.

    H Fillit, V Luine · Maturitas · 1997

    📄 PubMed で読む (PMID: 9147347)

  • Geriatric aspects on estrogen effects and sexuality.

    L B Sourander · Gerontology · 1994

    📄 PubMed で読む (PMID: 7851799)

  • Hormone therapy and risk of Alzheimer disease: a critical time.

    Susan M Resnick, Victor W Henderson · JAMA · 2002

    📄 PubMed で読む (PMID: 12413378)

  • Functional magnetic resonance imaging and estrogen effects on the brain: cautious interpretation of a BOLD finding.

    Victor W Henderson, Michael D Greicius · Menopause (New York, N.Y.) · 2010

    📄 PubMed で読む (PMID: 20944455)

  • Menopause and Brain Health: Neurobiological Changes, Cognitive Implications, and the Role of Estrogen.

    Keren Zhou, Madeline Cohn, Rachel Novik 他 · Obstetrics and gynecology clinics of North America · 2026

    The menopausal transition is characterized by significant hormonal fluctuations, culminating in a decline in estrogen levels. This decline impacts synaptic plasticity, neurotransmitter regulation, the blood brain barrier, cerebral blood flow, and metabolism, leading to cognitive symptoms often described as brain fog. Menopause-related cognitive changes, often transient, differ from the progressive…

    📄 PubMed で読む (PMID: 42508872)

  • Estradiol reduction during perimenopause is associated with lower BDNF, elevated inflammation, hippocampal loss, and cognitive decline.

    Shuaiting Liu, Zhen Huang, Yuhui Zeng 他 · Experimental gerontology · 2026

    The menopausal transition, defined by declining estradiol, disrupts neurotrophic and anti-inflammatory pathways, contributing to hippocampal and cognitive decline. In this longitudinal study, we examined 150 perimenopausal women and 80 premenopausal controls over 12 months, assessing estradiol levels, neurotrophic and inflammatory biomarkers, cognitive performance, and structural and functional hi…

    📄 PubMed で読む (PMID: 42364668)
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