ホーム › PubMed Lab 🤖 自分の AI で使う ⭐ 保存した論文

🔬 PubMed Lab

日本語で入力するだけで、PubMed の英語論文を検索できるリサーチアシスタントです。
卒論・研究テーマ探し、興味のある論文を効率よく見つけられます。

「マウスと魚で見えた「生きる力」の老化パターン」の検索結果

143 件中 10 件を表示 (3921 ms) · ⭐ 保存した論文

AI が生成した英語クエリを見る
(mice[MeSH] OR mouse OR murine) AND (fish[MeSH] OR zebrafish OR medaka) AND (aging[MeSH] OR ageing OR senescence) AND (vitality OR "life force" OR survival OR fitness OR healthspan OR lifespan)

💡 「生きる力」を vitality, survival, fitness, healthspan など複数の概念で表現し、マウスと魚類の老化パターン研究を幅広く検索

🎓 卒論・修論テーマを AI が提案

この 5 本の論文を俯瞰して、あなたが実際に卒論・修論で研究できるテーマを 3 つ提案します。

残り 3 / 3 回 (今日)

📖 このサイトの解説記事から (日本語で読める)

PubMed Trivia が過去に取り上げた論文を日本語で解説している記事です。

🔍 PubMed の検索結果

  • Hypoxia as a therapy for mitochondrial disease.

    Isha H Jain, Luca Zazzeron, Rahul Goli 他 · Science (New York, N.Y.) · 2016

    Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-mo…

    📄 PubMed で読む (PMID: 26917594)
  • The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells.

    Andreas O Mieland, Giuseppe Petrosino, Mario Dejung 他 · Leukemia · 2025

    Histone deacetylases (HDACs) comprise a family of 18 epigenetic modifiers. The biologically relevant functions of HDAC10 in leukemia cells are enigmatic. We demonstrate that human cultured and primary acute B cell/T cell leukemia and lymphoma cells require the catalytic activity of HDAC10 for their survival. In such cells, HDAC10 controls a MYC-dependent transcriptional induction of the DNA polyme…

    📄 PubMed で読む (PMID: 40301616)
  • Live fast, die young.

    Amber Dance · Nature · 2016

    📄 PubMed で読む (PMID: 27443744)
  • Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

    Jonathan B Baell, David J Leaver, Stefan J Hermans 他 · Nature · 2018

    Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function1. Among the genes coding for the MYST family of KATs (KAT5-KAT8) are the oncogenes KAT6A (also known as MOZ) and KAT6B (also known as MORF and QKF)2,3. KAT6A has essential roles in normal haematopoietic stem cells4-6 and is the target of recurrent chromosomal translocations, causing acu…

    📄 PubMed で読む (PMID: 30069049)
  • Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks.

    Katherine E Yutzey · Circulation research · 2017

    The inability of the adult heart to repair or regenerate is manifested in prevalent morbidity and mortality related to myocardial infarction and heart failure. Cardiomyocyte proliferation, especially after myocardial infarction or in the context of heart failure, has been an area of intense research by many investigators for decades. As a researcher working in this area for the past 25 years, this…

    📄 PubMed で読む (PMID: 28209795)
  • TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.

    Pauline Lascaux, Gwendoline Hoslett, Sara Tribble 他 · Cell · 2024

    DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes process topoisomerase 1 cleavage complexes (TOP1cc) DNA lesions in vertebrates. Selective degradation of TOP1cc by autophagy directs DNA damage repair and cell survi…

    📄 PubMed で読む (PMID: 39265577)
  • Humans: the ultimate animal models.

    Mary M Reilly, Alexander M Rossor · Journal of neurology, neurosurgery, and psychiatry · 2020

    📄 PubMed で読む (PMID: 32769113)
  • Is aging programed?

    Steven N Austad · Aging cell · 2004

    Development and morphogenesis may easily be thought of as programed, in the sense that they result from a sequence of cellular and molecular events designed by natural selection to produce a given adult phenotype. Aging, except in exceptional cases such as the rapid decay and death of Pacific salmon, is not design but decay. The decay of senescence is not due to natural selection's designing hand,…

    📄 PubMed で読む (PMID: 15379846)
  • Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1/P53 Signaling Pathway.

    Jialin Liang, Zang Ga, Jiaqin Wu 他 · International journal of molecular sciences · 2025

    Aging-related diseases have become a global health issue, with the escalating aging population leading to an increased disease incidence, placing immense pressure on individual health and society. Lycium ruthenicum Murray anthocyanins are hailed as the "Black Pearl of the Desert". Anthocyanins are potent natural antioxidants that can combat oxidation, reduce inflammation, prevent cardiovascular di…

    📄 PubMed で読む (PMID: 40429657)
  • 'Young poo' makes aged fish live longer.

    Ewen Callaway · Nature · 2017

    📄 PubMed で読む (PMID: 28406214)