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PubMed Trivia が過去に取り上げた論文を日本語で解説している記事です。
- 心理学 ポータブル視線追跡、アルツハイマー病・パーキンソン病の早期検出を大きく変える可能性 【意外な事実】持ち運べる視線追跡装置が、アルツハイマー病やパーキンソン病など神経疾患の認知機能変化を目の動きから検出できる可能性が示されている
- 心理学 運動とアルツハイマー病予防─効果が見られる時期に「窓」がある可能性 【意外な事実】運動習慣は認知症リスク低下と関連するが、介入効果が表れる時期には「狭い窓」がある可能性が示唆されている。
- 心理学 脳への微弱電流刺激が認知機能に関連 【ちょっと驚き】皮膚の上から脳に微弱な電流を流す「tDCS」という方法が、軽度認知障害やアルツハイマー病患者の認知機能スコアと関連していることが、1074人を対象にした22研究の統合解析で明らかになりました。
- 心理学 アルツハイマー病モデルマウスが示す行動変化の全体像 【知ってる？】アルツハイマー病研究で広く使われるマウスモデルは、生後2ヶ月でアミロイド沈着が始まり、4〜9ヶ月で運動・感覚・認知・精神症状まで多様な行動障害を示す
🔍 PubMed の検索結果
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Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study.
Models trained on accelerometer data have been proposed for detecting prodromal Parkinson's disease (PD). However, uncertainties in diagnosis timing in the UK Biobank (UKBB) may affect generalizability to other cohorts. The aim of the study was to evaluate the performance of previously published models for prodromal PD detection in other international cohorts. We applied the models to data from Ge…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Combined diagnosis for Parkinson's disease via gait and eye movement disorders.
With the discovery of the potential role of gait and eye movement disorders in Parkinson's disease (PD) recognition, we intend to investigate the combined diagnostic value of gait and eye movement disorders for PD. We enrolled some Chinese PD patients and healthy controls and separated them into the training and validation sets based on enrollment time. Performance in five oculomotor paradigms and…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer's Disease.
Wide-ranging functional defects in eye movements have been reported in Alzheimer's disease (AD) dementia. The detection of abnormal eye movements and reading problems may identify persons at risk of AD when clear clinical symptoms are lacking. To examine whether computer-based eye-tracking (ET) analysis of King-Devick (KD) test results differentiates cognitively healthy persons from persons with m…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Eye tracking - The overlooked method to measure cognition in neurodegeneration?
Eye tracking (ET) studies are becoming increasingly popular due to rapid methodological and technological advances as well as the development of cost efficient and portable eye trackers. Although historically ET has been mostly employed in psychophysics or developmental cognition studies, there is also promising scope to use ET for movement disorders and measuring cognitive processes in neurodegen…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Construction of a prediction model for Alzheimer's disease using an AI-driven eye-tracking task on mobile devices.
Eye-movement can reflect cognition and provide information on the neurodegeneration, such as Alzheimer's disease (AD). The high cost and limited accessibility of eye-movement recordings have hindered their use in clinics. We aim to develop an AI-driven eye-tracking tool for assessing AD using mobile devices with embedded cameras. 166 AD patients and 107 normal controls (NC) were enrolled. The subj…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Do you see what I see? Mobile eye-tracker contextual analysis and inter-rater reliability.
Mobile eye-trackers are currently used during real-world tasks (e.g. gait) to monitor visual and cognitive processes, particularly in ageing and Parkinson's disease (PD). However, contextual analysis involving fixation locations during such tasks is rarely performed due to its complexity. This study adapted a validated algorithm and developed a classification method to semi-automate contextual ana…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Deep Convolutional Neural Networks and Transfer Learning for Measuring Cognitive Impairment Using Eye-Tracking in a Distributed Tablet-Based Environment.
Alzheimer's disease (AD) is a neurodegenerative disorder that initially presents with memory loss in the presence of underlying neurofibrillary tangle and amyloid plaque pathology. Mild cognitive impairment is the initial symptomatic stage, which is an early window for detecting cognitive impairment prior to progressive decline and dementia. We recently developed the Visuospatial Memory Eye-Tracki…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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A Pilot Study: Automatically Monitoring the Physical Dysfunction of Idiopathic REM Sleep Behaviour Disorder with Wearables and Deep Learning.
Idiopathic Rapid eye movement (REM) sleep behavior disorder (iRBD) is considered a marker of Parkinson's disease (PD). The diagnosis and follow-up approach is video polysomnography (vPSG), which is too expensive to be accessible to the general population, and its precision could be affected by the first-night effect. Therefore, this study explores an economic approach to continuously monitoring iR…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Integrating Eye Tracking and Inertial Sensing for Enhanced Freezing of Gait Detection in Parkinson's Disease.
Freezing of gait (FOG), a disabling symptom in Parkinson's disease, presents a major challenge for wearable classification algorithms that struggle to distinguish freezes from voluntary stops. To address this ambiguity, we evaluated whether incorporating eye-gaze kinematics could improve classification accuracy compared to using ankle-mounted inertial measurement units (IMUs) alone. We analyzed da…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」
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Multimodal machine learning mobility assessment in Parkinson's disease within supervised and unsupervised settings.
BACKGROUND: Mobility in people with Parkinson’s disease (PwPD) is strongly context-dependent. Clinic-based assessments provide only brief snapshots under controlled conditions and may not reflect everyday functional capacity. Wearable sensors enable continuous free-living monitoring, yet most studies use unimodal signals and simple threshold-based walking detection. Multimodal sensing, combining s…
💬 論文と壁打ち β 残り 3 / 3 回 (今日)Abstract の内容だけを根拠に答えます。医療助言はしません。abstract に無い事実は「記載なし」と返します。質問例: 「要点を3つ教えて」「結論の限界は?」「N数と統計手法は?」「反論できる可能性は?」