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Sensory Processing Sensitivity in the context of Environmental Sensitivity: A critical review and development of research agenda.
Sensory Processing Sensitivity (SPS) is a common, heritable and evolutionarily conserved trait describing inter-individual differences in sensitivity to both negative and positive environments. Despite societal interest in SPS, scientific knowledge is lagging behind. Here, we critically discuss how SPS relates to other theories, how to measure SPS, whether SPS is a continuous vs categorical trait,…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.
The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care implementation in the U.K. National Health Service. Other parts of this project focus on patients with cancer and infection. We conducted a pilot study involving 4660 participants from 2183 …
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Sensory processing sensitivity: theory, evidence, and directions.
In recent years, scientific interest in sensory processing sensitivity (SPS), a personality trait reflecting increased sensitivity, reactivity, and deeper processing of stimuli, has grown exponentially. Building on this momentum, we synthesise recent SPS literature to discuss several central themes, including SPS assessment, relations to other personality traits and diverse positive and negative o…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.
Review. To formally introduce "degenerative cervical myelopathy" (DCM) as the overarching term to describe the various degenerative conditions of the cervical spine that cause myelopathy. Herein, the epidemiology, pathogenesis, and genetics of conditions falling under this hypernym are carefully described. Nontraumatic, degenerative forms of cervical myelopathy represent the commonest cause of spi…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Being highly sensitive person negatively impacts on cognitive and psychosocial fatigue in multiple sclerosis patients: A cross-sectional, monocenter study.
Fatigue is a common symptom in Multiple Sclerosis (MS), but its determinants are not clarified yet. Sensory processing sensitivity (SPS) is a personality trait characterized by enhanced sensitivity towards endogenous and exogenous stimuli, and higher attention toward minimal stimuli, resulting in overarousal and fatigue. to evaluate the association between SPS and fatigue in MS patients. 192 conse…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Combining Select Blood-Based Biomarkers with Neuropsychological Assessment to Detect Mild Cognitive Impairment among Mexican Americans.
Recent work has supported use of blood-based biomarkers in detection of amnestic mild cognitive impairment (MCI). Inclusion of neuropsychological measures has shown promise in enhancing utility of biomarkers to detect disease. The present study sought to develop cognitive-biomarker profiles for detection of MCI. Data were analyzed on 463 participants (normal control n = 378; MCI n = 85) from HABLE…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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A neuroimaging biomarker for striatal dysfunction in schizophrenia.
Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia1-5. We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification, prognosis and subtyping based on functional striatal abnormalities (FSA). FSA scores provide a personalized index of striatal dysfunction, ranging from normal to highly pathological. Using inte…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease.
To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of replication factor complex subunit 1 (RFC1) repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). Multimodal RFC1 repeat screening (PCR, Southern blot, whole-exome/genome sequencing-based appro…
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Deep Learning Modeling to Differentiate Multiple Sclerosis From MOG Antibody-Associated Disease.
Multiple sclerosis (MS) is common in adults while myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is rare. Our previous machine-learning algorithm, using clinical variables, ≤6 brain lesions, and no Dawson fingers, achieved 79% accuracy, 78% sensitivity, and 80% specificity in distinguishing MOGAD from MS but lacked validation. The aim of this study was to (1) evaluate the …
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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Do highly sensitive persons display hypersensitive narcissism? Similarities and differences in the nomological networks of sensory processing sensitivity and vulnerable narcissism.
Individuals with high sensory processing sensitivity (SPS) ("highly sensitive persons") are thought to be easily excitable and overwhelmed, highly attentive to aesthetic impressions, and particularly sensitive to sensory stimulation. Public discourse suggests that those who describe themselves as highly sensitive see themselves as fundamentally different from others, and view their personality as …
💬 Chat with AI about this paper (β) Remaining 3 / 3 todayAnswers use only the paper's abstract. Not medical advice. Missing info returns "not stated in abstract."Question examples: "Summarize the 3 key findings" · "Limitations?" · "N and statistical method?" · "Possible counter-argument?"
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